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We then conducted long, explicit-solvent thermodynamic integration TI simulations in an attempt to reproduce the experimental relative binding affinities of the inhibitor for the five mutants; in total, a combined simulation time of Sion Sono's Antiporno at Lido Cinema. The atomic scale interactions that occur at the interfaces between proteins are fundamental to all biological processes. Figure S6 Distribution of a backbone hydrogen bond in residues containing the T08I mutation. Gohlke H, Case DA. To investigate whether this binding contribution may be reduced in some circumstances, we have also investigated the T08A mutation in RADBRC4A a previously identified structural mutation derived from an equivalent cancer-associated mutation in BRC1.